Cellular Dynamics of Memory B Cell Populations: IgM+and IgG+Memory B Cells Persist Indefinitely as Quiescent Cells
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چکیده
منابع مشابه
Cellular Dynamics of Memory B Cell Populations: IgM+ and IgG+ Memory B Cells Persist Indefinitely as Quiescent Cells.
Despite their critical role in long-term immunity, the life span of individual memory B cells remains poorly defined. Using a tetracycline-regulated pulse-chase system, we measured population turnover rates and individual t1/2 of pre-established Ag-induced Ig class-switched and IgM-positive memory B cells over 402 d. Our results indicate that, once established, both IgG-positive and less freque...
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ژورنال
عنوان ژورنال: The Journal of Immunology
سال: 2015
ISSN: 0022-1767,1550-6606
DOI: 10.4049/jimmunol.1501365